GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2243480 | 1 | rs1723267 | chr7:65473314 | CCT6P1 | chr7:65216092-65228661:+ | 0.31 | 4.37 | 1.63E-5 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs1723269 | chr7:65472786 | CCT6P1 | chr7:65216092-65228661:+ | 0.32 | 4.35 | 1.79E-5 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs1723270 | chr7:65469830 | CCT6P1 | chr7:65216092-65228661:+ | 0.32 | 4.36 | 1.7E-5 | Diabetic kidney disease |
| BLCA | cis | rs1554120 | 1 | rs17290219 | chr3:150881774 | P2RY12 | chr3:151055238-151102544:- | 0.28 | 3.95 | 9.22E-5 | Heschl's gyrus morphology |
| BLCA | cis | rs80285556 | 1 | rs17311679 | chr19:50521331 | SIGLEC16 | chr19:50472912-50479075:+ | -0.6 | -5.72 | 2.13E-8 | antipsychotic drug dosage in schizophrenia or schizoaffective disorder |
| BLCA | cis | rs17433780 | 1 | rs17433780 | chr1:89474818 | GBP3 | chr1:89472367-89488549:- | 0.84 | 18.51 | 4.2E-55 | Carotid intima media thickness |
| BLCA | cis | rs17433780 | 1 | rs17433780 | chr1:89474818 | GBP7 | chr1:89597434-89641723:- | 0.26 | 4.38 | 1.53E-5 | Carotid intima media thickness |
| BLCA | cis | rs9475752 | 1 | rs17450853 | chr6:56788004 | BEND6 | chr6:56819773-56892138:+ | -0.28 | -4.11 | 4.75E-5 | Menarche (age at onset) |
| BLCA | cis | rs17496332 | 1 | rs17496332 | chr1:107546375 | PRMT6 | chr1:107599267-107601907:+ | 0.37 | 5.89 | 8.27E-9 | Sex hormone-binding globulin levels |
| BLCA | cis | rs7655841 | 1 | rs1757924 | chr4:130019599 | C4orf33 | chr4:130014829-130033842:+ | -0.34 | -5.65 | 3.13E-8 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs7655841 | 1 | rs1757925 | chr4:130020791 | C4orf33 | chr4:130014829-130033842:+ | 0.33 | 5.43 | 1.03E-7 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs7655841 | 1 | rs1757927 | chr4:130022069 | C4orf33 | chr4:130014829-130033842:+ | -0.33 | -5.42 | 1.04E-7 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs7655841 | 1 | rs1757928 | chr4:130022161 | C4orf33 | chr4:130014829-130033842:+ | -0.33 | -5.42 | 1.04E-7 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs7655841 | 1 | rs1757930 | chr4:130022356 | C4orf33 | chr4:130014829-130033842:+ | -0.34 | -5.5 | 6.99E-8 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs7655841 | 1 | rs1757935 | chr4:130023759 | C4orf33 | chr4:130014829-130033842:+ | -0.33 | -5.42 | 1.04E-7 | Chronic obstructive pulmonary disease (moderate to severe) |